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KMID : 0362919940120020143
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Journal of the Korean Society for Therapeutic Radiology and Oncology
1994 Volume.12 No. 2 p.143 ~ p.150
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Pathologic Changes in the Rabbit lung Following Single Dose irradiation
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Lee Hyung-Sik
Choi Young-Min
Hur Won-Joo
Jeong Jin-Sook
Yuh Young-Hyun
Lee Ki-Nam
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Abstract
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The damage which radiation produces in tissues such as the lungs can be discussed at the molecular, biophysical, cellular, and organ levels. The cellular effects of irradiating the lungs are related to the histologic and clinical sequelae. In the present study the right lung of rabbits were exposed to single dose of 20 Gy of X-irradiation.
Animals from each group were sacrificed monthly for 6 months postexposure. Sections of lung were examined by light microscopy(LM) and by transmission electron microscopy(TEM). Multiple exudative lesions were seen at 2 months after the 20Gy irradiation, and they progressed to a proliferative and then reparative fibrotic lesion by 6 months. Changes in epithelial lining of lung components, particulary the presence of type Ⅱ pneumocytes were found by both LM and TEM. Capillary endothelial damages were less pronounced. The possible implication of cellular components in radiation pneumonitis and fibrosis is discussed.
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KEYWORD
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Radiation pneumonitis, fibrosis, rabbit
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